Compound W: Full Drug Profile
Compound W - General Information
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Pharmacology of Compound W
Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
Additional information about Compound W
Compound W Indication: Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts. Mechanism Of Action: Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Salicyclic acid Synonyms: 2-Carboxyphenol; 2-Hydroxybenzenecarboxylic acid; 2-Hydroxybenzoic acid; Acido salicilico; O-carboxyphenol; O-hydroxybenzoic acid; Orthohydroxybenzoic acid; Phenol-2-carboxylic acid; SA; Salicylate; Salicylic acid Drug Category: Anti-Infective Agents; Antifungal Agents; Keratolytic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Salicyclic acid: Advanced pain relief callus removers; Advanced pain relief corn removers; Clear away wart remover; Compound W; Dr. Scholl's Callus Removers; Dr. Scholl's Corn Removers; Dr. Scholl's Wart Remover Kit; Duofil Wart Remover; Duoplant; Freezone; Ionil; Keralyt; Kyselina 2-hydroxybenzoova; Kyselina salicylova; Psoriacid-s-stift; Retarder SAX; Retarder W; Rutranex; SAX; Salicylic acid collodion; Salicylic acid soap; Saligel; Salonil; Stri-dex; Absorption: Not Available Toxicity (Overdose): Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Compound W: Gel Topical Powder Topical Liquid Topical Liquid Intravenous Patch Topical Ointment Topical Spray Topical Lotion Topical Plaster Topical Cream Topical Disc Topical Gel Topical Tablet Oral Shampoo Topical Solution / drops Oral Liquid Oral Stick Topical Solution Topical Powder Topical Chemical IUPAC Name: 2-hydroxybenzoic acid Chemical Formula: C7H6O3 Salicyclic acid on Wikipedia: https://en.wikipedia.org/wiki/Salicyclic_acid Organisms Affected: Humans and other mammals